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KMID : 0361419970210010229
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Journal of Korean Academy of Rehabilitation Medicine
1997 Volume.21 No. 1 p.229 ~ p.233
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Adverse Side Effect of Baclofen -Case Report-
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김동연
최선미/김영섬/오승현/이진
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Abstract
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Baclofen(B-4-chlorphyl-r-amino butyric acid), a centrally acting gamma amino butyric acid (GABA) agonist is a commonly used pharmaceutics for spasticity of spinal cord lesion. It's effect includes activation of GABA receptor in primary sensory
afferent,
enhancement of Ranshow cell activity and depression of fusimotor response. It is primarily excreted by glomerullar filtration with a clearance proportional to creatinine clearance. It's popularity is a result of the antispastic effect and the
lack
of
toxic effect on organ. But, transient drowsiness is the most common neurological side effect with therapeutic dose of the drugs. We report here two patients who developed an acute side effects after being treated with relative therapeutic dose of
baclofen.
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